CD27 expression on lymphocyte and sCD27 levels in children with asthma

Bozdogan G., DOĞU E. F., Guloglu D., Yuksek M., Aytekin C., İKİNCİOĞULLARI K. A.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, cilt.38, sa.6, ss.327-332, 2010 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 6
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.aller.2010.02.008
  • Dergi Adı: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.327-332
  • Anahtar Kelimeler: CD27 expression, Soluble CD27 level, Asthma, Children, CELL DIFFERENTIATION ANTIGEN, SOLUBLE CD27, T-LYMPHOCYTES, ACTIVATION ANTIGEN, SUBSETS, RELEASE, FAMILY
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: CD27, a lymphocyte specific member of the Tumour Necrosis Factor-Receptor (TNF-R) family is expressed on the majority of peripheral blood T cells. Activation of T cells via TCR/CD3 induces high CD27 surface expression and release of a soluble form (sCD27) of the molecule. sCD27 level increases in patients suffering from a variety of chronic inflammatory diseases. In the present study we aimed to measure both the serum sCD27 levels and CD27 expression on T cells in asthmatic patients, to evaluate the state of this molecule in allergic inflammation.