Akademik Veri Yönetim Sistemi
European Association of Neurosurgical Societies, Sofija, Bulgaristan, 13 - 17 Ekim 2024, ss.150-151
Background: Predicting the aggressiveness of meningiomas may influence the
surgical strategy timing. Because of the paucity of robust markers, the systemic
immune-inflammation (SII) index is a novel biomarker to be an independent
predictor of poor prognosis in various cancers including gliomas. We aimed to
investigate the value of SII as well as neutrophil-lymphocyte ratio (NLR) and
platelet-lymphocyte ratio (PLR) indices in predicting prognosis.
Methods: Records including demographic, clinical, and laboratory datas of patients
operated on due to intracranial meningioma in 2017–2023 were retrospectively
reviewed.
Results: A total of 234 patients were included in this study. All of SII index, NLR
and PLR values at presentation were significantly higher in grade 2 meningiomas.
A positive correlation was observed between SII index and Ki67 index (r ¼
0.313; p < 0.001); between NLR and Ki67 index (r ¼ 0.330; p < 0.001); and
between PLR and Ki67 index (r ¼ 0.223; p < 0.01). SII index (optimal cutoff level
> 618), NLR (optimal cutoff level > 3.53) and PLR (optimal cutoff level > 121.2)
showed significant predictive values.
Conclusions: This is the first study to assess the prognostic value of the SII index
in patients with intracranial meningiomas. Increased SII index, NLR and PLR
were correlated with higher grade and higher Ki-67 index. They also harbor the
potential to screen patients that may need more aggressive treatments or more
frequent follow-up examinations.