Synthesis and antimicrobial activity of some 2-[p-substituted-phenyl]benzoxazol-5-yl-arylcarboxyamides

ARPACI Ö., Aki-Sener E., Yalcin I., Altanlar N.

ARCHIV DER PHARMAZIE, vol.335, no.6, pp.283-288, 2002 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 335 Issue: 6
  • Publication Date: 2002
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.283-288
  • Keywords: benzoxazole-5-yl-arylcarboxyamides, antibacterial and antifungal activity, REVERSE-TRANSCRIPTASE INHIBITORS, MICROBIOLOGICAL ACTIVITY, 2-PYRIDINONE DERIVATIVES, BENZIMIDAZOLES, BENZOXAZOLES, BENZOTHIAZOLES, ANALOGS, UK-1, OXAZOLO(4,5-B)PYRIDINES, ANTIFUNGAL
  • Ankara University Affiliated: Yes

Abstract

New 2-[p-substituted-phenyl]benzoxazol-, 5-yl-arylcarboxyam ides derivatives have been synthesized by reacting 5-amino-2-[p-substituted-phenyl]benzoxazoles with substituted-arylcarboxylic acid chlorides. The structures of the synthesized compounds were confirmed by IR and H-1 NMR spectral data. Antimicrobial activities of the compounds were investigated using the two-fold serial dilution technique against different Gram-positive and Gram-negative bacteria and the yeast C. albicans in comparison with standard drugs. Microbiological results indicated that the synthesized compounds possess a broad spectrum of activity, having an MIC value of 25-200 mug/mL at molar concentration values of 3.45 x 10(-5) and 5.74 x 10(-4) against the tested microorganisms.