Subcutaneous versus sublingual immunotherapy for allergic rhinitis and/or asthma

BAHÇECİLER N., Cobanoglu N.

Immunotherapy, cilt.3, sa.6, ss.747-756, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 3 Sayı: 6
  • Basım Tarihi: 2011
  • Doi Numarası: 10.2217/imt.11.48
  • Dergi Adı: Immunotherapy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.747-756
  • Anahtar Kelimeler: allergic rhinitis, asthma, subcutaneous immunotherapy, sublingual immunotherapy, GRASS-POLLEN IMMUNOTHERAPY, HOUSE-DUST MITE, LOCAL NASAL IMMUNOTHERAPY, HUMAN ORAL-MUCOSA, T-CELL TOLERANCE, QUALITY-OF-LIFE, DOUBLE-BLIND, DENDRITIC CELLS, TGF-BETA, IMMUNOLOGICAL MECHANISMS
  • Ankara Üniversitesi Adresli: Hayır

Özet

Subcutaneous allergen-specific immunotherapy has long been used in allergic rhinitis and/or asthma and has been recognized to be efficacious. However, owing to the inconvenience of injection and the risk of serious side effects, alternative concepts inspiring the search for effective noninjective routes, namely sublingual administration of allergens, have emerged. Sublingual immunotherapy (SLIT) appears to be associated with a lower incidence of systemic reactions. The clinical efficacy of subcutaneous immunotherapy (SCIT) is well established for both rhinitis and asthma. Meta-analyses relating to its efficacy on asthma and rhinitis are available. SLIT has also been validated in this respect. Comparative clinical studies of SLIT versus SCIT are scarce demonstrating both routes to be clinically efficient. Knowledge of the exact mechanism of action of SLIT has been increasing in the last decade. In addition, recent studies have proved similarities of the immunological changes with the treatment of both routes. Further comparative clinical and immunological studies of SLIT versus SCIT are needed to confirm the long-term efficacy and to complete the knowledge of immunological mechanisms of both routes. Moreover, better understanding of the interaction of allergen and oral mucosal dendritic cells during SLIT may allow improved targeting of SLIT vaccines. © 2011 Future Medicine Ltd.