Tryptophan Metabolites: A Microbial Perspective

ENGİN E. D.

TRYPTOPHAN METABOLISM: IMPLICATIONS FOR BIOLOGICAL PROCESSES, HEALTH AND DISEASE, pp.75-94, 2015 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Publication Date: 2015
  • Doi Number: 10.1007/978-3-319-15630-9_4
  • Journal Name: TRYPTOPHAN METABOLISM: IMPLICATIONS FOR BIOLOGICAL PROCESSES, HEALTH AND DISEASE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.75-94
  • Keywords: Tryptophan, Quorum sensing, Pseudomonas quinolone signalling, Indole, Antimicrobial, ESCHERICHIA-COLI, INTERSPECIES COMMUNICATION, SHIKIMATE PATHWAY, GENE-EXPRESSION, VIBRIO-HARVEYI, INDOLE, MECHANISMS, SIGNAL, BIOSYNTHESIS, ANTIBIOTICS
  • Ankara University Affiliated: Yes

Abstract

The discovery of the regulation of tryptophan biosynthetic pathway by means of a repressible operon has been recognised as a milestone in genetics. This long multistep pathway is energetically so expensive that numerous allosteric control loops exist in addition to tight genetic regulation. That's why essential amino acid tryptophan is a valuable product for food industry and animal breeding. Traditionally, vitamin auxotrophs of soil microorganisms have been used for amino acid manufacturing. However, in the age of synthetic biology, metabolic engineering has recently become the method of choice to construct the producer strains.