Tryptophan Metabolites: A Microbial Perspective

ENGİN E. D.

TRYPTOPHAN METABOLISM: IMPLICATIONS FOR BIOLOGICAL PROCESSES, HEALTH AND DISEASE, ss.75-94, 2015 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/978-3-319-15630-9_4
  • Dergi Adı: TRYPTOPHAN METABOLISM: IMPLICATIONS FOR BIOLOGICAL PROCESSES, HEALTH AND DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.75-94
  • Anahtar Kelimeler: Tryptophan, Quorum sensing, Pseudomonas quinolone signalling, Indole, Antimicrobial, ESCHERICHIA-COLI, INTERSPECIES COMMUNICATION, SHIKIMATE PATHWAY, GENE-EXPRESSION, VIBRIO-HARVEYI, INDOLE, MECHANISMS, SIGNAL, BIOSYNTHESIS, ANTIBIOTICS
  • Ankara Üniversitesi Adresli: Evet

Özet

The discovery of the regulation of tryptophan biosynthetic pathway by means of a repressible operon has been recognised as a milestone in genetics. This long multistep pathway is energetically so expensive that numerous allosteric control loops exist in addition to tight genetic regulation. That's why essential amino acid tryptophan is a valuable product for food industry and animal breeding. Traditionally, vitamin auxotrophs of soil microorganisms have been used for amino acid manufacturing. However, in the age of synthetic biology, metabolic engineering has recently become the method of choice to construct the producer strains.