DEVELOPMENT AND CHARACTERIZATION OF GELATIN/CHITOSAN/MONTMORILLONITE COMPOSITE SCAFFOLD ENRICHED WITH MAGNESIUM

KOÇ DEMİR A.

REVUE ROUMAINE DE CHIMIE, cilt.64, sa.4, ss.327-335, 2019 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.33224/rrch.2019.64.4.05
  • Dergi Adı: REVUE ROUMAINE DE CHIMIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.327-335
  • Anahtar Kelimeler: bone tissue engineering, composite material, montmorillonite, natural polymers, magnesium, CHITOSAN, BIODEGRADATION
  • Ankara Üniversitesi Adresli: Hayır

Özet

In this study, gelatin/chitosan/montmorillonite (G/CS/MMT) composite scaffold was developed, where MMT was enriched with Mg2+ to improve the osteogenic properties. Mg2+ modified and unmodified G/CS/MMT scaffold with an interconnected porous structure was produced by the freeze drying method. The physicochemical and morphological properties of the composite scaffold were evaluated using XRD, FT-IR, TGA, MIP, and SEM. Mechanical strength of the scaffold was investigated. The release of Mg2+ from G/CS/MMT into the phosphate buffer was determined by the inductively-coupled plasma optical emission spectroscopy. The results showed that Mg2+ modified G/CS/MMT composite scaffold may be a promising biomaterial for bone tissue engineering.