Colon targeted drug delivery systems Kolona hedeflenen i̇laç taşiyici si̇stemler

ŞENGEL TÜRK C. T., HASÇİÇEK C., Gönül N.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.35, sa.2, ss.125-148, 2006 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 35 Sayı: 2
  • Basım Tarihi: 2006
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.125-148
  • Anahtar Kelimeler: Colon, Colon targeting, Colonic drug delivery systems, Peptides-proteins
  • Ankara Üniversitesi Adresli: Evet

Özet

Colon targeted drug delivery systems have the potential to deliver drugs for the treatment of a variety of colonic diseases and to deliver proteins and peptides to the colon for their systemic absorption. In recent years, various pharmaceutical approaches have been developed for targeting the drugs to the colon include, formation of prodrugs, coating of pH-sensitive polymers, use of colon specific biodegradable polymers, time depended and pressure controlled drug delivery systems. In this review; physiology of colon and available technologies of colon targeted drug delivery systems were evaluated.