Melatonin analogue new indole hydrazide/hydrazone derivatives with antioxidant behavior: Synthesis and structure-activity relationships

Gurkok G., ÇOBAN T., SÜZEN S.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.24, sa.2, ss.506-515, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/14756360802218516
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.506-515
  • Anahtar Kelimeler: Indole, hydrazone, hydrazide, melatonin, synthesis, antioxidant activity, IN-VITRO ANTIOXIDANT, 2-PHENYLINDOLE DERIVATIVES, LIPID-PEROXIDATION, RAT
  • Ankara Üniversitesi Adresli: Evet

Özet

Melatonin (MLT) is a hormone produced in the brain by the pineal gland, from the amino acid tryptophan. It is also an antioxidant hormone with a particular role in the protection of nuclear and mitochondrial DNA. In recent years, many physiological properties of MLT have been described resulting in much attention in the development of synthetic compounds possessing the indole ring. Sixteen MLT analogue indole hydrazide/hydrazone derivatives were synthesized and in vitro antioxidant activity was investigated. Most of the compounds showed significantly higher activity than MLT at 10-3M and 10-4M concentrations.