The role of COMT polymorphism in modulation of prefrontal activity during verbal fluency in bipolar disorder

Devrimci-Ozguven H., Alici Y. H., DEMİRBÜGEN ÖZ M., SÜZEN H. S., Kale H. E., Baskak B.

NEUROSCIENCE LETTERS, vol.738, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 738
  • Publication Date: 2020
  • Doi Number: 10.1016/j.neulet.2020.135310
  • Journal Name: NEUROSCIENCE LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Animal Behavior Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Bipolar disorder, Verbal fluency, COMT, FNIRS, CATECHOL-O-METHYLTRANSFERASE, WORKING-MEMORY, VAL(158)MET GENOTYPE, EUTHYMIC PATIENTS, DOPAMINE, GENE, NIRS, SCHIZOPHRENIA, METAANALYSIS, PERFORMANCE
  • Ankara University Affiliated: Yes

Abstract

Objective: Verbal fluency (VF) impairment is a strong predictor of social functioning in bipolar disorder (BPD). The enzyme catechol-O- methyltransferase (COMT) has a critical role in cognitive responses by modulating dopaminergic activity in the prefrontal cortex (PFC). Here, we investigated the role of COMT polymorphism (i) in VF performance as well as (ii) in modulation of PFC activity during a VF-task in euthymic BPD patients.