The impact of vitamin D deficiency on clinical, biochemical and metabolic parameters in primary hyperparathyroidism El impacto de la deficiencia de vitamina D en los parámetros clínicos, bioquímicos y metabólicos en el hiperparatiroidismo primario

Şengül Ayçiçek G., Aydoğan B. İ., ŞAHİN M., EMRAL R., ERDOĞAN M. F., GÜLLÜ S., ...Daha Fazla

Endocrinologia, Diabetes y Nutricion, cilt.70, sa.1, ss.56-62, 2023 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.endinu.2022.06.006
  • Dergi Adı: Endocrinologia, Diabetes y Nutricion
  • Derginin Tarandığı İndeksler: Scopus, EMBASE, MEDLINE, DIALNET
  • Sayfa Sayıları: ss.56-62
  • Anahtar Kelimeler: Adenoma size, Hypertension, Metabolic syndrome, Nephrolithiasis, Obesity, Osteoporosis, Primary hyperparathyroidism, Vitamin D deficiency
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2022 SEEN y SEDBackground: It has been suggested that vitamin D deficiency is associated with worse clinical outcomes in primary hyperparathyroidism (PHPT). We aimed to evaluate the relationship between vitamin D deficiency and clinical, biochemical and metabolic parameters in PHPT patients. Methods: A total of 128 patients with biochemically confirmed PHPT were included. Patients were categorized as vitamin D deficient if 25-OH vitamin D was <50 nmol/L, or normal if vitamin D was ≥50 nmol/L. Biochemical parameters, bone mineral densitometry (BMD), and urinary tract and neck ultrasonography were assessed. Results: In the study group, 66 (51.6%) patients had vitamin D deficiency and 60 (48.4%) had normal vitamin D levels. Nephrolithiasis and osteoporosis were found in 26.6% and 30.5% of subjects, respectively. The prevalence of metabolic syndrome (MetS), obesity (BMI ≥30 kg/m2) and hypertension (HTN) were higher in the vitamin D deficient group when compared to the normal group (p = 0.04, p = 0.01 and p = 0.03, respectively). There was no difference regarding the presence of nephrolithiasis and osteoporosis between the groups. The mean adenoma size was similar in both groups. Conclusions: Vitamin D deficiency was not associated with osteoporosis, nephrolithiasis, adenoma size or biochemical parameters in PHPT. However, vitamin D deficiency may be a risk factor for developing HTN and MetS in PHPT.