Hepatoprotective and TNF-alpha inhibitory activity of Zosima absinthifolia extracts and coumarins
FITOTERAPIA, cilt.82, sa.3, ss.454-459, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 82 Sayı: 3
- Basım Tarihi: 2011
- Doi Numarası: 10.1016/j.fitote.2010.12.007
- Dergi Adı: FITOTERAPIA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.454-459
- Anahtar Kelimeler: (+)-Columbianadin, (-)-Deltoin, Furanocoumarin, Hepatoprotective activity, TNF-alpha, Zosima
- Ankara Üniversitesi Adresli: Evet
Özet
Zosima absinthifolia (ZA) extracts and the coumarins (+)-columbianadin and (-)-deltoin were evaluated for their potential hepatoprotective and antiinflamatory effects in a CCl4-induced hepatotoxicity assay in rats and by the inhibition of TNF-alpha production on LPS-stimulated THP-1 macrophages, respectively. Both the ZA extracts and the coumarins showed hepatoprotective activity confirmed by monitoring the ALT/AST levels and by histopathological examination. The antiinflamatory activity, proved by the inhibition of TNF-alpha production, was found to be higher for the n-hexane root extract than for coumarins, suggesting synergic potential of the extract. The concentration of (-)-deltoin and (+)-columbianadin in extracts was determined by HPLC analysis. (c) 2011 Elsevier B.V. All rights reserved.