Vaccines Against Cancer

Baydın P., Korgan E., Akbulut H.

CURRENT APPROACHES IN CANCER IMMUNOTHERAPY, Prof. Dr. Asuman Sunguroğlu, Editör, Türkiye Klinikleri Yayınevi, Ankara, ss.1-89, 2025

  • Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
  • Basım Tarihi: 2025
  • Yayınevi: Türkiye Klinikleri Yayınevi
  • Basıldığı Şehir: Ankara
  • Sayfa Sayıları: ss.1-89
  • Editörler: Prof. Dr. Asuman Sunguroğlu, Editör
  • Ankara Üniversitesi Adresli: Evet

Özet

ABS TRACT Recent data indicate that immunotherapy may be the most effective treatment method because

it is more specific to cancer cells and the response rate of patients to treatment is higher. Cancer

vaccine studies developed to eliminate the immunosuppressive effect of the tumor microenvironment

(TME) and prevent tumor cells from escaping the immune system have gained great importance. The

structure, method of administration, advantages and disadvantages of cancer vaccines vary depending on

different factors, especially TME conditions. Combined treatments that can be administered together

with the vaccine can increase vaccine effectiveness. Neoantigens, known as tumor-specific antigens

(TSAs), are not found in normal cells and developed as a result of various mutations in cancer cells.

Identification of neoantigens in tissue, sequencing, typing, evaluation in databases, production in different

vaccine forms and application alone or with combined treatments are the main steps of personalized

treatments, as well as eliminating tumor resistance and increasing clinical effectiveness. In this section,

cancer vaccines and personalized cancer vaccines developed with neoantigens are summarized in a general

and brief manner.