Effect of factor VIIIc levels in pediatric stroke patients
PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.21, no.3, pp.255-260, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 21 Issue: 3
- Publication Date: 2004
- Doi Number: 10.1080/08880010490277024
- Journal Name: PEDIATRIC HEMATOLOGY AND ONCOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.255-260
- Keywords: factor V, factor VIII, prothrombin, stroke, 20210 G-A, ISCHEMIC-STROKE, PROTHROMBOTIC DISORDERS, RISK-FACTORS, CHILDREN, THROMBOSIS, MUTATION, INFANTS
- Ankara University Affiliated: No
Abstract
Twenty consecutive patients with ischemic stroke confirmed by magnetic resonance imaging and 40 healthy age-matched controls were enrolled in the study. Thirteen of the patients had an underlying disease and/or risk factors. Infection was the most common underlying factor (4 patients). Four patients had heterozygote FVL and 3 patients showed heterozygosity for PT 20210A. A weak positive association between FV1691A and high FVIIIc levels ( r = -.110) was determined. Comparison of the prevalence of high FVIIIc levels in patients and healthy subjects with and without FVL/PT 20210 indicated that high FVIII levels are an independent risk factor.