Torsade de pointes associated with moxifloxacin: A rare but potentially fatal adverse event

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Altin T., Ozcan O., Turhan S., Ozdemir A., Akyurek O., Karaoguz R., ...Daha Fazla

CANADIAN JOURNAL OF CARDIOLOGY, sa.11, ss.907-908, 2007 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/s0828-282x(07)70850-4
  • Dergi Adı: CANADIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.907-908
  • Anahtar Kelimeler: moxifloxacin, torsade de pointes, QT INTERVAL, PROLONGATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Torsade de pointes occuring due to a long QT interval is a rare but potentially fatal arrhythmia. Acquired long QT develops most commonly because of drugs that prolong, ventricular repolarization. It has been reported that fluoroquinolone antimicrobials prolong the corrected QT interval but rarely cause torsade de pointes. A patient with torsade de pointes risk factors (fen-tale sex, advanced age, extreme bradycardia and renal failure) who developed the condition on the fourth day of 400 mg/day of oral moxifloxacin treatment is presented. After the rnoxifloxacin was stopped, the corrected QT interval normalized and a permanent cardiac pacemaker was implanted. During 11 months Of follow-up, arrhythmia did not recur.