PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age

Clyman, Ronald; Liebowitz, Melissa; Kaempf, Joseph; Erdeve, ÖMER; Bulbul, Ali; Hakansson, Stellan; Lindqvist, Johanna; Farooqi, Aijaz; Katheria, Anup; Sauberan, Jason; Singh, Jaideep; Nelson, Kelly; Wickremasinghe, Andrea; Dong, Lawrence; Hassinger, Denise; Aucott, Susan; Hayashi, Madoka; Heuchan, Anne; Carey, William; Derrick, Matthew; Fernandez, Erika; Sankar, Meera; Leone, Tina; Perez, Jorge; Serize, Arturo; Fields, Scott; Whitten, Lora; Rogers, Stefanie; Okulu, EMEL; Tunc, Gaffari; Uçar, TAYFUN; Unal, Ebru; Steen, Jane; Arnell, Kathy; Holtschlag, Sarah; Schreiber, Michael; Peters, Caryn; Gilmore, Maureen; Mckay, Lorna; Carole, Dianne; Shaw, Annette; Harris, Malinda; Amsbaugh, Amy; Liedl, Lavonne; Wolf, Sue; Groner, Avi; Kimball, Amy; Kim, Jae; Bridge, Renee; Knodel, Ellen; Weng, Chrissy; Barbosa, Magaly; Polin, Richard; Weindler, Marilyn; Noori, Shahab; Reese, Jeffrey; Sun, Yao

doi:10.1016/j.jpeds.2018.09.012

PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age

Clyman R. I., Liebowitz M., Kaempf J., Erdeve Ö., Bulbul A., Hakansson S., ...More

JOURNAL OF PEDIATRICS, vol.205, pp.41-54, 2019 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 205
Publication Date: 2019
Doi Number: 10.1016/j.jpeds.2018.09.012
Journal Name: JOURNAL OF PEDIATRICS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.41-54
Open Archive Collection: AVESIS Open Access Collection
Ankara University Affiliated: Yes

Abstract

Objective To compare early routine pharmacologic treatment of moderate-to-large patent ductus arteriosus (PDA) at the end of week 1 with a conservative approach that requires prespecified respiratory and hemodynamic criteria before treatment can be given.