Efficiency of topical treatment in psoriasis with 1,25-dihydroxycholecalciferol


BOZKIR A., Gurgey E., Kazeruni H.

Turkish Journal of Medical Sciences, cilt.26, sa.1, ss.63-67, 1996 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 1
  • Basım Tarihi: 1996
  • Dergi Adı: Turkish Journal of Medical Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.63-67
  • Anahtar Kelimeler: 1,25-dihydroxycholecalciferol, psoriasis vulgaris
  • Ankara Üniversitesi Adresli: Evet

Özet

The two different ointment concentrations of 1-25(OH)2D3 were applied to 45 persons who were suffering psoriasis. These were the best formulas which have been used until this time. When 100 μg/g 1-25(OH)2D3 ointments which had been applied for about 8 weeks, in 78.2% cases have been completely recovered, the other 17.4% have been mild, the other 4.4% have been limited recovery. When we applied 50 μg/g of 1-25(OH)2D3 ointment for about 9 weeks in the case of 63.7% have been full recovery, the case of 22.8% have been moderate, 4.5% have been limited recovery was seen. In the case of 9%, the ointment have not been effected. In this study, different types of psoriasis vulgaris were taken. These two concentrations and the recovery time were analysed by statistical test. We observed that, in all types of psoriasis vulgaris, the time of recovery and the concentration of 1-25(OH)2D3 ointment showed direct proportion (p < 0.05). During the therapy we haven't seen topic and systemic side effect.