High-dose chemotherapy with peripheral blood progenitor cell support for patients with non-small cell lung cancer: The experience of the European Group for Bone Marrow Transplantation (EBMT) Solid Tumours Working Party

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De Giorgi U., Blaise D., Lange A., Viens P., Marangolo M., Madroszyk A., ...Daha Fazla

BONE MARROW TRANSPLANTATION, cilt.40, sa.11, ss.1045-1048, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 11
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1038/sj.bmt.1705880
  • Dergi Adı: BONE MARROW TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1045-1048
  • Anahtar Kelimeler: non-small cell lung cancer, high-dose chemotherapy, peripheral blood progenitor cells, carboplatin, COLONY-STIMULATING FACTOR, IFOSFAMIDE, CARBOPLATIN, ETOPOSIDE, SURVIVAL, STANDARD
  • Ankara Üniversitesi Adresli: Evet

Özet

We report the experience of the EBMT Solid Tumours Working Party (STWP) using high-dose chemotherapy (HDCT) with PBPC support in patients with non-small cell lung cancer (NSCLC). Between 1989 and 2004, 36 NSCLC patients (27 men and 9 women), median age 53.5 years (range: 24-62) were treated with 63 HDCT courses. A high-dose carboplatin-based regimen was used in 53% of the cases. Thirty-two patients had relapsed/metastatic disease, while four classified as stage IIIB received HDCT followed by radiotherapy. No treatment- related death occurred. Of 25 patients who were planned to receive multi-cycle HDCT, 4 cases (16%) interrupted the treatment early due to prolonged severe toxicities and 4 (16%) due to progressive disease. Of 36 evaluable patients, 3 (8%) achieved a complete remission and 13 (36%) had a partial remission at an overall response rate of 44%. Of these, one patient with stage IIIB and one with stage IV are alive disease free at 71+ and 149+ months, respectively. After a median follow-up of 48 months (range: 6-149), median survival was 7 months (range: 1-149). Despite one anecdotal case, HDCT did not show significant activity, but induced relevant morbidity in NSCLC patients.