Ergotamine enhances acetylcholine-induced relaxation in various vascular segments of rabbits

DEMİREL YILMAZ E., Cankat Tulunay F., Kazim Türker R.

European Journal of Pharmacology, cilt.159, sa.2, ss.195-198, 1989 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 159 Sayı: 2
  • Basım Tarihi: 1989
  • Doi Numarası: 10.1016/0014-2999(89)90706-1
  • Dergi Adı: European Journal of Pharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.195-198
  • Anahtar Kelimeler: Acetylcholine, Endothelium, Endothelium-derived relaxing factor (EDRF), Ergotamine, Vascular segments
  • Ankara Üniversitesi Adresli: Evet

Özet

The vasodilator response to acetylcholine and betanechol in segments of rabbit carotid, superior mesenteric and femoral arteries preconstricted with phenylephrine and with intact endothelium was enhanced when the vessels were preincubated with ergotamine but not with ergometrine for 60 min or longer. The vasodilator response to acetylcholine and its enhancement by ergotamine were completely prevented after methylene blue pretreatment or endothelium removal. These results were taken as evidence that the potentiation by ergotamine of the vasodilator response to acetylcholine is probably due to an increased production of EDRF from the vascular endothelium. © 1989.