Effect of subcarınal lymph node posıtıvıty on survıval ın N2 non-small cell lung cancer

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Aktürk İ., Baloğlu S., Kahya Y., Kocaman G., Yenigün B. M., Özkan M., ...Daha Fazla

32nd Meeting of the European Society of Thoracic Surgeons, Barcelona, İspanya, 26 - 28 Mayıs 2024, ss.528-529

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Barcelona
  • Basıldığı Ülke: İspanya
  • Sayfa Sayıları: ss.528-529
  • Ankara Üniversitesi Adresli: Evet

Özet

OBJECTIVES

It is recommended to divide N2 disease into two groups in the analysis of data collected for 9th staging of non-small cell lung cancer (NSCLC): single (N2a) station or multiple (N2b) stations. The goal is to reduce the heterogeneity in N2 disease. Even if it were a single station, the effect of subcarinal lymph node (LN) positivity on staging is still a matter of debate. This study is designed to investigate how subcarinal LN positivity effects survival in patients with resectable N2 NSCLC.

METHODS

148 pT1-4N2M0 patients who were operated on for NSCLC between 2008 and 2023 in the Department of Thoracic Surgery of the University Hospital were retrospectively evaluated. Patients were divided into 3 groups: N2a subcarinal LN negative (Group1), N2a subcarinal LN positive (Group2) and N2b. These patients were analyzed in terms of age, gender, clinical and pathological stage, N2a/N2b and subcarinal LN metastasis status and overall survival.

RESULTS

The gender distribution of the patients was female/male = 23/125, and the average age was 60.6 (min/max 24/80) years. Patient numbers per groups were: Group 1 (n=59), Group 2 (n=35), Group 3 (n=54). The 5-year survival for all was 58%, median survival was 67 months. Survival according to groups were: Group 1 (57%), Group 2 (62%), Group 3 (57%). There was no statistical difference in survival between groups (p = 0.779) (Figure 1).

CONCLUSIONS

N2 disease is associated with heterogeneity and poor prognosis. The prognostic effect of the subcarinal LN metastasis, which is located at the center of the lymphatic network, is still unclear. In this study, there was no statistically signifi cant survival difference between subcarinal LN negative and positive N2a patients. This result shows regardless of the LN station number, N2 disease is a systemic disease rather than a locoregional disease. Multicenter studies on this subject are needed.