Akademik Veri Yönetim Sistemi
11th Annual Symposium on Physical and Analytical Chemistry (ASPAC 2022), Tbilisi, Gürcistan, 8 - 10 Aralık 2022
Meconium is the first stool of newborns and begins to form from about the 12th week of
pregnancy, and is excreted within 48 hours of birth. There are severe doubts that the phthalate
esters, bisphenol analogs and triclosan investigated in our study may cause some neurological
and hormonal problems, especially in children in the developmental age. Although there are
many studies on phthalate esters and bisphenol analogs, the number of studies done especially
to determine the amount of exposure in the womb is very few. Due to the short half-life of these
substances in the organism, the maternal urine, plasma, and the first urine of the baby used in the
studies, unfortunately, do not adequately reflect the amount of exposure during pregnancy.
Because of its inert nature, meconium can become a pool for short-lived substances such as
phthalate esters and bisphenol analogs in the organism. Therefore, a new extraction and gas
chromatography/mass spectrometry method was developed and validated. With the developed
method, meconium samples belonging to one hundred different newborns were analyzed and the
method was evaluated widely. The amounts of phthalate esters, bisphenol analogs, and triclosan to which the fetus was exposed were determined. The average of the results obtained from
meconium samples analyzed with the developed method, monomethyl phthalate 10.96 ng/g,
monoethyl phthalate 1.7 ng/g, monobutyl phthalate 2.78 ng/g, bisphenol AF 1.09 ng/g, bisphenol
F 2.45 ng/g, bisphenol A 1.72 ng/g, bisphenol S 2.88 ng/g and triclosan 3.54 ng/g.
Acknowledgments
This work was supported by Ankara University Scientific Research Projects Coordination,
Ankara, Turkey (21L0217001)