Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myocardial infarction

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GÜLEÇ H. S., Aras O., Akar E., TUTAR D. E., Omurlu K., Avci F., ...Daha Fazla

CLINICAL CARDIOLOGY, cilt.24, sa.4, ss.281-284, 2001 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 4
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1002/clc.4960240405
  • Dergi Adı: CLINICAL CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.281-284
  • Anahtar Kelimeler: methylenetetrahydrofolate reductase gene, myocardial infarction, CORONARY-ARTERY DISEASE, HEART-DISEASE, 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE, MILD HYPERHOMOCYSTEINEMIA, VASCULAR-DISEASE, COMMON MUTATION, PLASMA HOMOCYST(E)INE, HOMOCYSTEINE, POPULATION, FOLATE
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Elevated plasma homocysteine level is an independent risk factor for cardiovascular disease. A common mutation (nucleotid 677C-T) in the gene coding for methylenetetrahydrofolate reductase (MTHFR) has been reported to reduce the enzymatic activity of MTHFR and is associated with elevated plasma levels of homocysteine, especially in subjects with low folate intake.