Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myocardial infarction

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GÜLEÇ H. S., Aras O., Akar E., TUTAR D. E., Omurlu K., Avci F., ...More

CLINICAL CARDIOLOGY, vol.24, no.4, pp.281-284, 2001 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 4
  • Publication Date: 2001
  • Doi Number: 10.1002/clc.4960240405
  • Journal Name: CLINICAL CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.281-284
  • Keywords: methylenetetrahydrofolate reductase gene, myocardial infarction, CORONARY-ARTERY DISEASE, HEART-DISEASE, 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE, MILD HYPERHOMOCYSTEINEMIA, VASCULAR-DISEASE, COMMON MUTATION, PLASMA HOMOCYST(E)INE, HOMOCYSTEINE, POPULATION, FOLATE
  • Open Archive Collection: AVESIS Open Access Collection
  • Ankara University Affiliated: Yes

Abstract

Background: Elevated plasma homocysteine level is an independent risk factor for cardiovascular disease. A common mutation (nucleotid 677C-T) in the gene coding for methylenetetrahydrofolate reductase (MTHFR) has been reported to reduce the enzymatic activity of MTHFR and is associated with elevated plasma levels of homocysteine, especially in subjects with low folate intake.