Akademik Veri Yönetim Sistemi
European Journal of Immunogenetics, cilt.28, sa.2, ss.358, 2001 (SCI-Expanded)
Hematopoetic stem cell transplantation is a life saving procedure for many diseases. However small family size is the main limiting factor against finding a HLA identical sibling donor. The chances of having a HLA identical sibling can be calculated from the formula 1-(0.75)n. This question has not been addressed in our country where approximately 100 allogeneic BMT's are being done.A bone marrow donor registry which consist of 1250 donors has been established in our Department since 1996. In this study we aimed to analyze the rate of finding an identical donor in a calendar year(2000). We analyzed 414 possible donors for 114 patients with the age of 1-72 (median:32) and various diagnoses(AML, n=39; CML,n=33; ALL,n=19, Aplastic Anemia, n=6; MDS, n=5; Multiple Myeloma,n=3; miscellaneous, n=39).122 patients were from our Department, 22 from other hospitals. Seventeen of these were admitted for retyping and 9 of them had already HLA class I identical donors. For the rest, retyping ended with similar results. For 3 patients additional donors were typed without finding a donor. For 62 patients we were able to to find a suitable sibling donor out of 135 patients (45.9%). Sibling number ranged between 0-7(median =2). Calculated probabilism for 2 siblings is 0.45. Complete family search was performed for 16 patients,and 3 were successful; grand uncle, father and son were found to be identical due to consanguinity between parents. In the absence of consanguinity for Class I II, 1-3 Ag similarities between parents were observed. A1, A2, A3, A24, B51,B35, DR11, DR4, DR2antigens were observed in our population more frequently compared to BMDW records. During 2000, 16 targeted cord blood units were cryopreserved where 2 were found to be HLA identical. Surprisingly, we also found the mother to be a suitable donor, again due to inbred marriage(second degree cousin) To summarize we were able to find identical related donors in 65/151 patients (43.4%).This value is comparable with the calculated value for a median of 2 siblings. Unrelated donor search within our registry couldn't reveal a suitable donor. International research was successful 2/5 and is under formal search. In conclusion, our center was more efficient in finding related donors compared to unrelated ones due to the family size and other factors. © 2001 Blackwell Science Ltd,.