CD8(+) cytotoxic mycosis fungoides: a retrospective analysis of clinical features and follow-up results of 29 patients


Kalay Yildizhan İ., ŞANLI H., Akay B. N., Surgun E., HEPER A.

INTERNATIONAL JOURNAL OF DERMATOLOGY, cilt.59, sa.1, ss.127-133, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1111/ijd.14689
  • Dergi Adı: INTERNATIONAL JOURNAL OF DERMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.127-133
  • Ankara Üniversitesi Adresli: Evet

Özet

Background and objective Less than 5% of cases of mycosis fungoides (MF) present with a cytotoxic/suppressor CD8(+) phenotype. This study aimed to evaluate the clinical characteristics, treatment modalities, and clinical course in CD8(+) MF patients. Methods In a retrospective analysis of 353 MF patients in a referral center at Ankara University, Turkey, 29 patients that were diagnosed with CD8(+) MF were included in the study. Results CD8(+) MF cases constituted 8.2% of all MF patients. The age at the time of diagnosis ranged between 6 and 81 years with a median value of 46 years. The female-to-male ratio was 1.41. Patients presented with erythematous scaly (69%), hyperpigmented (58.6%), poikilodermic (17.2%), and hypopigmented (17.2 %) patches/plaques. The most common sites of involvement were the trunk and lower extremities. The most common comorbidity was hypertension (24.1%, n: 7) with 13 patients (44.8%) having a history of at least one autoimmune disease. At the time of diagnosis, 93.2% of the patients had early-stage disease, and 6.8% of the patients had advanced stage. The mean follow-up period was 6.68 +/- 6.04 years (range 1-28 years). Most of the patients were treated with skin-directed therapies. Complete remission was achieved in 17 (58.6%) patients, eight (27.6%) patients had partial remission, and four (13.8%) patients had stable disease. Conclusions We concluded that CD8(+) MF is associated with an indolent course and in most patients, skin-directed therapies were found to be efficient to control the disease.