Role of O-GlcNAcylation and endoplasmic reticulum stress on obesity and insulin resistance
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.44, no.5, pp.599-610, 2019 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 44 Issue: 5
- Publication Date: 2019
- Doi Number: 10.1515/tjb-2018-0303
- Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.599-610
- Keywords: O-GlcNAc, ER stress, Insulin resistance, Obesity, Adipose tissue, UNFOLDED PROTEIN RESPONSE, ER STRESS, GLUCOSE, CONSEQUENCES, MECHANISMS, EXPRESSION, PATHWAY
- Ankara University Affiliated: Yes
Abstract
Background: Obesity is a global public health problem. Obesity closely associated with various metabolic diseases such as; insulin resistance, hypertension, dys-lipidemia and cardiovascular diseases. Endoplasmic reticulum (ER) stress is a critical factor for insulin resistance. O-linked N-acetyl-glucosamine (O-GlcNAc); is the post-translational modification which is has a vital role in biological processes; including cell signaling, in response to nutrients, stress and other extracellular stimuli.