Role of O-GlcNAcylation and endoplasmic reticulum stress on obesity and insulin resistance

Sermikli B. P., Aydogdu G., Taghidizaj A. A., YILMAZ E.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.44, sa.5, ss.599-610, 2019 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 5
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1515/tjb-2018-0303
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.599-610
  • Anahtar Kelimeler: O-GlcNAc, ER stress, Insulin resistance, Obesity, Adipose tissue, UNFOLDED PROTEIN RESPONSE, ER STRESS, GLUCOSE, CONSEQUENCES, MECHANISMS, EXPRESSION, PATHWAY
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Obesity is a global public health problem. Obesity closely associated with various metabolic diseases such as; insulin resistance, hypertension, dys-lipidemia and cardiovascular diseases. Endoplasmic reticulum (ER) stress is a critical factor for insulin resistance. O-linked N-acetyl-glucosamine (O-GlcNAc); is the post-translational modification which is has a vital role in biological processes; including cell signaling, in response to nutrients, stress and other extracellular stimuli.