Role of O-GlcNAcylation and endoplasmic reticulum stress on obesity and insulin resistance

Sermikli B. P., Aydogdu G., Taghidizaj A. A., YILMAZ E.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.44, no.5, pp.599-610, 2019 (SCI-Expanded, Scopus, TRDizin) identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 5
  • Publication Date: 2019
  • Doi Number: 10.1515/tjb-2018-0303
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.599-610
  • Keywords: O-GlcNAc, ER stress, Insulin resistance, Obesity, Adipose tissue, UNFOLDED PROTEIN RESPONSE, ER STRESS, GLUCOSE, CONSEQUENCES, MECHANISMS, EXPRESSION, PATHWAY
  • Ankara University Affiliated: Yes

Abstract

Background: Obesity is a global public health problem. Obesity closely associated with various metabolic diseases such as; insulin resistance, hypertension, dys-lipidemia and cardiovascular diseases. Endoplasmic reticulum (ER) stress is a critical factor for insulin resistance. O-linked N-acetyl-glucosamine (O-GlcNAc); is the post-translational modification which is has a vital role in biological processes; including cell signaling, in response to nutrients, stress and other extracellular stimuli.