Natural course of acquired vitelliform lesions associated with pigment epithelial detachments in dry age related macular degeneration.

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Atıf İçin Kopyala

YANIK ODABAŞ Ö., DEMİREL S., Batioglu F., ÖZMERT E.

European journal of ophthalmology, cilt.31, sa.6, ss.3133-3141, 2021 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 31 Sayı: 6
• Basım Tarihi: 2021
• Doi Numarası: 10.1177/1120672121990566
• Dergi Adı: European journal of ophthalmology
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE
• Sayfa Sayıları: ss.3133-3141
• Anahtar Kelimeler: Age-related macular degeneration, retina, medical therapies, techniques of retinal examination, retinal pathology, research, CHOROIDAL NEOVASCULARIZATION
• Ankara Üniversitesi Adresli: Evet

Özet

Purpose: To describe the natural history of acquired vitelliform lesions (AVLs) associated with different types of pigment epithelial detachments (PEDs) in dry age-related macular degeneration. Methods: A retrospective review of clinical examination and multimodal imaging data of patients with AVLs associated with PED(s) was performed. Results: This study included 25 eyes of 17 patients. The mean age of patients was 67.2 +/- 9.7 (47-83) years. The mean follow-up time was 32.6 +/- 16.2 (12-66) months, excluding four patients (five eyes) that were lost to follow-up. The mean logMAR BCVA was 0.21 +/- 0.16 at baseline and 0.38 +/- 0.28 at final visit (p = 0.016). At the end of the follow-up period, PEDs enlarged in eight eyes (40%) and were unchanged in two eyes (10%). Spontaneous resolution of the central PED(s) with AVLs was seen in four (20%) eyes. Rupture of the PED(s) occurred in four eyes (20%), with two developing central foveolar atrophy afterwards. Overall, central foveolar atrophy was seen ultimately in four eyes (20%). Conclusion: It seems that high PED size may be a risk factor for PED rupture during follow-up. 1/3 of the eyes ended up with unfavorable anatomical outcome.