A review of infectious complications after haploidentical hematopoietic stem cell transplantations

Atilla E., Atilla P. A., CİVRİZ BOZDAĞ S., DEMİRER T.

INFECTION, vol.45, no.4, pp.403-411, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 45 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.1007/s15010-017-1016-1
  • Journal Name: INFECTION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.403-411
  • Keywords: Infections, Haploidentical hematopoietic stem cell transplantation, Bacterial, Viral, Fungal, HIGH-DOSE CHEMOTHERAPY, TOTAL-BODY IRRADIATION, INVASIVE FUNGAL DISEASES, VERSUS-HOST-DISEASE, SYNGENEIC MARROW TRANSPLANTATION, CHRONIC MYELOGENOUS LEUKEMIA, ACUTE MYELOID-LEUKEMIA, BONE-MARROW, BREAST-CANCER, RISK-FACTORS
  • Ankara University Affiliated: Yes

Abstract

Background Allogeneic hematopoietic stem cell transplantation from haploidentical donor is a feasible option for patients with hematological diseases who lack a suitable HLA-matched donor, but viral and fungal infections are still the most common causes of morbidity and mortality in haploidentical transplantation setting because of delayed immune reconstitution, increased risk of graft vs host disease (GvHD) or systemic steroid use. Therefore, this review will focus on the infectious complications after haploidentical hematopoietic stem cell transplantation (HSCT).