Incomplete Antibodies May Reduce ABO Cross-Match Incompatibility: A Pilot Study

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Ozen M., Yilmaz S., ÖZKAN T., Ozer Y., Pekel A. A., SUNGUROĞLU A., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.35, no.1, pp.54-60, 2018 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.4274/tjh.2016.0504
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.54-60
  • Keywords: Transfusion medicine, Red blood cells, Complications, Humoral immune response, CELL TRANSPLANTATION, HEMOLYTIC-ANEMIA, FAB FRAGMENTS, AUTOANTIBODY, DISEASE, SERUM
  • Open Archive Collection: AVESIS Open Access Collection
  • Ankara University Affiliated: Yes

Abstract

Objective: Any erythrocyte transfusion among humans having type A or B blood groups is impossible due to antibodies causing fatal transfusion complications. A cross-match test is performed to prevent immune transfusion complications before transfusion. Our hypothesis is that the fragment antibody (Fab) part of the antibody (incomplete antibody) may be used to prevent an immune stimulus related to the complete antibody. Therefore, we designed a pilot study to evaluate the effectiveness of these incomplete antibodies using cross-match tests.