Incomplete Antibodies May Reduce ABO Cross-Match Incompatibility: A Pilot Study

Creative Commons License

Ozen M., Yilmaz S., ÖZKAN T., Ozer Y., Pekel A. A., SUNGUROĞLU A., ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.35, sa.1, ss.54-60, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4274/tjh.2016.0504
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.54-60
  • Anahtar Kelimeler: Transfusion medicine, Red blood cells, Complications, Humoral immune response, CELL TRANSPLANTATION, HEMOLYTIC-ANEMIA, FAB FRAGMENTS, AUTOANTIBODY, DISEASE, SERUM
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Any erythrocyte transfusion among humans having type A or B blood groups is impossible due to antibodies causing fatal transfusion complications. A cross-match test is performed to prevent immune transfusion complications before transfusion. Our hypothesis is that the fragment antibody (Fab) part of the antibody (incomplete antibody) may be used to prevent an immune stimulus related to the complete antibody. Therefore, we designed a pilot study to evaluate the effectiveness of these incomplete antibodies using cross-match tests.