Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.29, sa.1, ss.215-220, 2009 (SCI-Expanded)
Thyroid hormone (TH) is a key regulatory factor of the normal brain developmental programme possibly throughout fetal and extrauterine life. In addition to its role in cellular metabolic activity, TH is critically involved in growth, development, and function of the central nervous system. Enviromental factors that interfere with thyroid function or TH action may produce deleterious effects on brain development by interfering with TH action in the developing brain. All degrees of iodine deficiency affect thyroid function of the mother and the neonate as well as the mental development of the child. Experimental studies and clinical research have clarified not only the correlation between nervous system maturation and tyhroid function during early development stages but also excess and deficient THs can cause permanent anatomo-functional alterations to the nervous system. If the TH deficiency occurs early in pregnancy, the off spring display problems invisual attention, visual processing and gross motor skills. Also the effect of THs is known on the putative neurotransmitter systems, that regulate mood and behaviour. Copyright © 2009 by Türkiye Klinikleri.