The Effect of Intracerebroventricular Injection of Beta Amyloid Peptide (1-42) on Caspase-3 Activity, Lipid Peroxidation, Nitric Oxide and NOS Expression in Young Adult and Aged Rat Brain

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Cetin F., YAZIHAN N., DİNCER S., Akbulut G.

TURKISH NEUROSURGERY, cilt.23, sa.2, ss.144-150, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5137/1019-5149.jtn.5855-12.1
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.144-150
  • Anahtar Kelimeler: Beta amyloid, Caspase 3 activity, Lipid peroxidation, Nitric oxide, Nitric oxide synthase, Hippocampus, Aging, ALZHEIMERS-DISEASE, OXIDATIVE STRESS, INCREASES, APOPTOSIS, NEURONS, NEUROTOXICITY, HIPPOCAMPUS, GLUTATHIONE, SYSTEM
  • Ankara Üniversitesi Adresli: Evet

Özet

AIM: Intracerebroventricular (icy) administration of beta amyloid peptide (A beta) in rats can be used to model certain aspects of Alzheimer disease (AD).The purpose of this study was to examine the effects of intracerebroventricular A(3 (1-42) peptide injection on caspase-3 activity and expression of nNOS and iNOS, malondialdehyde (MDA), glutathione (GSH) and NOx in the hippocampus, temporal cortex and parietal cortex.