Gold Nanoparticle-Lignan Complexes Inhibited MCF-7 Cell Proliferation in vitro: A Novel Conjugation for Cancer Therapy

BAKAR ATEŞ F., ÇAĞLAYAN M. G., Onur F., Nebioglu S., PALABIYIK İ. M.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.15, sa.3, ss.336-344, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2174/1871520614666141202144152
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.336-344
  • Anahtar Kelimeler: Antiproliferative, beta-CD - AuNP, characterization, complex, lignan, MCF-7 cell, MAMMALIAN LIGNANS, PHARMACEUTICAL APPLICATIONS, INDUCE APOPTOSIS, PROSTATE-CANCER, GROWTH, BREAST, TUMOR, PINORESINOL, CYCLODEXTRINS, METASTASIS
  • Ankara Üniversitesi Adresli: Evet

Özet

Nanoparticles, including gold nanoparticles (AuNP), have been used in imaging in cancer treatment and as therapeutic agents and drug delivery vehicles. Particularly lignans, also called phytoestrogens, have strong effects on the treatment of carcinomas due to their antiestrogenic, antiangiogenic and proapoptotic mechanism. The aim of this study is to investigate the antiproliferative effects of three lignans-AuNP conjugates, pinoresinol (PINO), lariciresinol (LARI) and secoisolariciresinol (SECO), on the MCF-7 cell lines. For this purpose, first, thiolated beta-cyclodextrin (beta-CD) was synthesized to achieve a surface modification of AuNP, and then the beta-CD modified AuNP was characterized using the transmission electron microscopy (TEM), UV-Visible and Nuclear Magnetic Resonance (NMR) spectroscopy. Then, the selected lignans were conjugated to the beta-CD-modified AuNP, and the antiproliferative effect of these conjugates was monitored. The results suggest that when compared to their non-conjugated forms, the AuNP-bound lignan conjugates prevented the proliferation of the MCF-7 cells significantly. Therefore, these AuNP-conjugated derivatives can be new candidate agents for breast cancer therapy.