The Activity of Adenosine Deaminase and Dipeptidyl Peptidase IV in Children With Attention Deficit Hyperactivity Disorder
JOURNAL OF ATTENTION DISORDERS, cilt.28, sa.1, ss.25-30, 2024 (SCI-Expanded, SSCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 1
- Basım Tarihi: 2024
- Doi Numarası: 10.1177/10870547231197212
- Dergi Adı: JOURNAL OF ATTENTION DISORDERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, CINAHL, MEDLINE, Psycinfo
- Sayfa Sayıları: ss.25-30
- Anahtar Kelimeler: attention deficit hyperactivity disorder, ADA, DPP IV, child, SUPEROXIDE-DISMUTASE, DEFICIT/HYPERACTIVITY DISORDER, PROLYL ENDOPEPTIDASE, MAJOR DEPRESSION, XANTHINE-OXIDASE, NITRIC-OXIDE, BIOMARKERS
- Ankara Üniversitesi Adresli: Evet
Özet
Objective: In this study, to investigate the place of T cell-mediated immunity in the etiology of ADHD, for which we do not have enough information; we aimed to investigate the activity of DPP IV and ADA, which are T cell-related enzymes, and the relationship of these enzymes with ADHD symptoms in children with ADHD. Methods: Twenty-seven children aged 6 to 12 years with a diagnosis of attention deficit hyperactivity disorder and 27 children aged 6 to 12 years without any psychiatric disease were included in the study. Results: While serum ADA and DPP-IV activity were found to be statistically significantly higher in the group with ADHD. There was no statistically significant correlation between serum ADA and DPP-IV activities and CTRS-R-L and CPRS-R-L in both groups. Conclusion: We think that T cell mediated inflammation may play a role in the etiology of ADHD due to changes in ADA and DPP-IV levels in children.