Hydroxyl and superoxide radical scavenging abilities of chromonyl-thiazolidine-2,4-dione compounds

Kruk I., BOZDAĞ DÜNDAR O., Ertan R., Aboul-Enein H. Y., Michalska T.

Luminescence, cilt.24, sa.2, ss.96-101, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/bio.1077
  • Dergi Adı: Luminescence
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.96-101
  • Anahtar Kelimeler: Chemiluminescence, Chromonyl-thiazolidine-2,4-dione compounds, ESR, Radical-scavenging ability
  • Ankara Üniversitesi Adresli: Evet

Özet

The oxygen free radical scavenging activities of 15 chromonyl-thiazolidine-2,4-dione compounds (CTDs) were examined in chemical systems producing superoxide anion radicals, O2* (potasium superoxide-18-crown-6 ether-DMSO), and hydroxyl radicals, HO* (a Fenton reaction: Fe(II)-H2O2-sodium trifluoroacetate, pH 6.15). Chemiluminescence and electron spin resonance (ESR) spectroscopy using 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) as spin trap were applied to evaluate antioxidant behaviour of CTDs towards the oxygen radicals. The results indicated that 11 of the 15 tested compounds showed a significant inhibitory effect on the chemiluminescence generated from the O2*-generating system, ranging from 41 to 86%, and 13 CTDs quenched the ESR signal of the DMPO-OH spin adduct by 33-86%, at a concentration of 1 mmol L-1. Our findings demonstrate that CTDs could be good free radical scavengers. © 2008 John Wiley & Sons, Ltd.