Akademik Veri Yönetim Sistemi
HAEMA, cilt.9, sa.1, ss.134-138, 2006 (Scopus)
An 18-year-old male patient, who presented with fever, perspiration, sputum, right hand lateral pain and stomach ache, was diagnosed as having acute acute blastic transformation of chronic eosinophilic leukaemia (CEoL). His haematology profile at diagnosis was as follows: haemoglobin 9.1 g/dl, haematocrit 38.3%, leukocyte count 106.1×109/l (differential count: eosinophils 95%, blast cells 4-5%), and platelet count 142×10 9/L. The bone marrow aspiration revealed an eosinophilic infiltration, which accounted for more than 95% of the granulocytic series. Eosinophils of both peripheral blood and marrow were positive in periodic acid Sniff (PAS) and naphtol chloroacetate esterase staining. Cytogenetic analysis revealed a t(5;14)(q31;q32) translocation. To our knowledge, this translocation is described for the first time in the blast crisis of CEoL. The interleukin-3 (IL-3) gene localized in 5q 31 is fused with the IgH (immunoglobulin heavy chain) gene localized in 14q32; thus, the resultant fusion gene increases IL-3 secretion, which is a pivotal cytokine for the differentiation of the eosinophil series. Copyright © Hellenic Society of Haematology.