Antinociceptive and anti-inflammatory activities of Viburnum opulus

ALTUN M. L., Citoglu G. S., SEVER YILMAZ B., Ozbek H.

PHARMACEUTICAL BIOLOGY, cilt.47, sa.7, ss.653-658, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 7
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/13880200902918345
  • Dergi Adı: PHARMACEUTICAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.653-658
  • Anahtar Kelimeler: Anti-inflammatory activity, antinociceptive activity, median lethal dose (LD50), Viburnum opulus, VIBSANE-TYPE DITERPENES, DILATATUM THUNB., TRADITIONAL MEDICINE, IRIDOID GLUCOSIDES, TRITERPENOIDS, GAMAZUMI, PLANTS, ACID, MICE
  • Ankara Üniversitesi Adresli: Evet

Özet

Water extract of Viburnum opulus L. (Caprifoliaceae) (VO) leaf was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that VO causes dose related inhibition in acetic acid-induced abdominal stretching in mice. VO inhibited abdominal stretching at 100 and 200 mg/kg. VO showed antinociceptive activity, which was quantified by the tail-flick test at doses of 100 and 200 mg/kg. However, VO did not have an anti-inflammatory effect at these doses. The LD50 of VO was determined as 5.447 g/kg.