Akademik Veri Yönetim Sistemi
Journal de Pharmacie de Belgique, cilt.53, sa.3, ss.263, 1998 (Scopus)
Flunarizine is a selective calcium entry blocker, widely used in cerebral and peripheral vascular disorders. To our knowledge, no information about the electrochemical redox properties of flunarizine and its analytical applications have appeared in the literature. In this work, we carried out a study of the oxidation behaviour of the drug at the glassy carbon electrode. Flunarizine was characterized by a single, irreversible and diffusion controlled oxidation peak at about + 1.3 V (vs SCE) in 0.5 M H2SO4 with 20% methanol. Voltammograms recorded at scan rate of 100 mVs-1 showed that the drug can be determined in the entire concentration range 6×10-6M to 2×10-4 M (i[μA] = 2.80 + 2.92×105C[M] r=0.9987). This characteristic was applied for determination of flunarizine in capsules without any preceding and time consuming separation. Furthermore, to obtain comparative results, a first derivative UV spectrophotometric method was also developed, which was applicable to flunarizine capsules avoiding any risks of matrix interferences.