Impact of Cribriform Pattern on Progression-Free Survival After Radical Prostatectomy in Gleason Score 8-10 Prostate Cancer

Walburn T., TUAÇ Y., Aktan Ç., Argun O., Chen L. W., Yang D. D., ...Daha Fazla

Eurasian Journal of Medicine, cilt.57, sa.1, 2025 (ESCI, Scopus, TRDizin) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.5152/eurasianjmed.2025.25804
  • Dergi Adı: Eurasian Journal of Medicine
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Anahtar Kelimeler: Cribriform pattern, progression-free survival, prostate cancer, radical prostatectomy
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Although extensive research highlights the detrimental effect of cribriform pattern 4 (CP4) on survival in non-high-risk prostate cancer (PC), its prognostic significance in high-risk PC is not well understood. Methods: The individual patient data from the The Cancer Genome Atlas (TCGA) database following radical prostatectomy was retrospectively examined. A predefined statistical analysis was conducted to evaluate the potential association between CP4 and progression-free survival (PFS). Results: Of the 135 patients examined, CP4 was present in 66 (48.9%). Median follow-up was 45.93 months (interquartile range: 22.87, 80.10). Cribriform pattern 4 was associated with a significantly reduced PFS (sub-distribution hazard ratio, 1.99; 95% CI, 1.01-3.92; P = .045) following adjustment for covariates. Conclusions: The presence of CP4 in high-risk Gleason 8-10 PC portends worse PFS. Further studies are warranted to fully understand its implications in risk stratification and post-operative management of PC.