Cyclosporine reduces hepatic antioxidant capacity: protective roles of antioxidants

Durak I., Ozbek H., Elgün Ülkar S.

INTERNATIONAL IMMUNOPHARMACOLOGY, vol.4, no.3, pp.469-473, 2004 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 4 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1016/j.intimp.2004.01.018
  • Journal Name: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.469-473
  • Keywords: cyclosporine, liver, antioxidant capacity, peroxidation, TRANSPLANT RECIPIENTS, INDUCED HEPATOTOXICITY, ALLOGRAFT RECIPIENTS, HYDROGEN-PEROXIDE, VITAMIN-E, THERAPY, BLOOD, RAT, NEPHROTOXICITY, RADICALS
  • Ankara University Affiliated: Yes

Abstract

The immunosuppressive agent cyclosporine A (CsA) has been reported to exert measurable hepatotoxic effects. One of the causes leading to hepatotoxicity is thought to be reactive oxygen radical formation. Therefore, this study was designed to elucidate possible relation between cyclosporine A treatment and antioxidant capacity (AOC) of hepatic tissue and, to determine if antioxidant supplementation is beneficial.