Cyclosporine reduces hepatic antioxidant capacity: protective roles of antioxidants

Durak I., Ozbek H., Elgün Ülkar S.

INTERNATIONAL IMMUNOPHARMACOLOGY, cilt.4, sa.3, ss.469-473, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.intimp.2004.01.018
  • Dergi Adı: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.469-473
  • Anahtar Kelimeler: cyclosporine, liver, antioxidant capacity, peroxidation, TRANSPLANT RECIPIENTS, INDUCED HEPATOTOXICITY, ALLOGRAFT RECIPIENTS, HYDROGEN-PEROXIDE, VITAMIN-E, THERAPY, BLOOD, RAT, NEPHROTOXICITY, RADICALS
  • Ankara Üniversitesi Adresli: Evet

Özet

The immunosuppressive agent cyclosporine A (CsA) has been reported to exert measurable hepatotoxic effects. One of the causes leading to hepatotoxicity is thought to be reactive oxygen radical formation. Therefore, this study was designed to elucidate possible relation between cyclosporine A treatment and antioxidant capacity (AOC) of hepatic tissue and, to determine if antioxidant supplementation is beneficial.