Immunosuppressive therapy-induced hepatotoxicity in patients with aplastic anemia

Dilek I., İDİLMAN R., Fenkci S., Ustun C., KOÇ H., İLHAN O., ...Daha Fazla

Turkish Journal of Haematology, cilt.17, sa.3, ss.111-117, 2000 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 3
  • Basım Tarihi: 2000
  • Dergi Adı: Turkish Journal of Haematology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.111-117
  • Anahtar Kelimeler: Antithymocyte/antilymphocyte globulin, Aplastic anemia, Hepatotoxicity, Immunosuppressive therapy, Liver
  • Ankara Üniversitesi Adresli: Evet

Özet

Immunosuppressive therapy is a treatment for aplastic anemia patients who are not candidates for hematopoietic stem cell transplantation. The aim of the study to evaluate the frequency and severity of immunosuppressive therapy-induced hepatotoxicity in patients with aplastic anemia. The records of 27 patients with aplastic anemia who had received immunosuppressive therapy were received and determined for evidence of hepatotoxicity. The patients were divided into three groups. Group 1 was treated with antithymocyte/antilymphocyte globulin and cyclosporin A, group 2 received only cyclosporin-A and group 3 was treated with antithymocyte/antilymphocyte globulin + cyclosporin-A and granulocyte macrophage colony-stimulating factor. All patients in group 1 had an initial increase in AST and ALT levels after therapy, but these tests abnormalities returned to normal in each case (p>0.05). There was no detectable change in AST and ALT levels in group 2 (p>0.05). In group 3, five patients had an increase in ALT and AST levels in the initial several days after therapy was started but the levels gradually returned to normal by the second or third week of therapy.