Akademik Veri Yönetim Sistemi
Journal of Public Health (Germany), cilt.20, sa.6, ss.585-592, 2012 (Scopus)
Aim There is currently no data available regarding hypersensitivity reactions to drugs in an adult population in Turkey. The aim of this study was to determine the prevalence of self-reported drug hypersensitivity reactions among adults in Turkey and related factors. Subjects and methods A structured self-administered questionnaire was sent to the parents of 6th grade elementary students who represented different socioeconomic levels of populations in Ankara/Turkey. Results A total of 1,370 adults (mean age: 23.88±6.48 years, female/male: 710/660) responded to the survey. The prevalence of self-reported drug hypersensitivity was 13.4% (183/1,370). The most frequently drugs involved were beta-lactams (n063, 34.4%), followed by nonsteroidal anti-inflammatory drugs (n052, 28.4%), general anesthetics (n029, 15.8%) and radio contrast media (n025, 13.7%). Factors related with reported reactions were age (p<0.0001, odds ratio: 2.27); personal history of allergic (p: 0.001, odds ratio: 7.32), nonallergic diseases (p<0.0001, odds ratio: 39.93), and family history of drug hypersensitivity (p<0.0001, odds ratio: 17.00). Less than half of the subjects had solicited medical assistance during the acute stages of a reaction and 9.7% of them had been referred to an allergist for further evaluation of a drug allergy. Conclusion This survey showed that self-reported hypersensitivity reactions to drugs are highly prevalent among parents of elementary students and its prevalence seems to be affected by age, personal allergic and nonallergic diseases, and family history of drug hypersensitivity. © Springer-Verlag 2012.