Soluble endothelial protein C receptor levels in Behcet patients with and without ocular involvement

YALÇINDAĞ F. N., ŞERMET F., Özdemir Ö., Cansizoǧlu E., Eǧin Y., Akar N.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, cilt.246, sa.11, ss.1603-1608, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 246 Sayı: 11
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s00417-008-0873-9
  • Dergi Adı: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1603-1608
  • Anahtar Kelimeler: Behcet's disease, endothelial cell-activated protein C receptor, soluble endothelial cell-activated protein C receptor, ocular involvement, FACTOR-V-LEIDEN, GENE G20210A MUTATIONS, PLASMA-LEVELS, EPCR GENE, RISK-FACTOR, VASCULAR INVOLVEMENT, SEPCR LEVELS, ACTIVATION, EXPRESSION, VESSELS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background The protein C system is an important natural anticoagulant mechanism. Endothelial cell-activated protein C receptor (EPCR), which was discovered at the surface of endothelial cells, binds protein C and enhances its activation. The soluble form of EPCR (sEPCR) has been detected in plasma. Behcet's disease is a chronic inflammatory disorder affecting multiple organs. Arterial and venous thrombosis is a common clinical manifestation of Behcet's disease and the pathogenic mechanism of thrombotic tendency in the disease is not well known. The aim of this study is to determine sEPCR concentrations in Behcet patients with and without ocular involvement as well as to investigate the association between sEPCR levels and clinical manifestations of Behcet's disease.