Idiopathic Orbital Inflammation: Review of Literature and New Advances

Yesiltas Y. S., GÜNDÜZ A. K.

MIDDLE EAST AFRICAN JOURNAL OF OPHTHALMOLOGY, cilt.25, sa.2, ss.71-80, 2018 (ESCI, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 25 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4103/meajo.meajo_44_18
  • Dergi Adı: MIDDLE EAST AFRICAN JOURNAL OF OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.71-80
  • Anahtar Kelimeler: Corticosteroids, dacryoadenitis, idiopathic orbital inflammation, myositis, pseudotumor, CLINICAL-FEATURES, SCLEROSING INFLAMMATION, MYCOPHENOLATE-MOFETIL, MYOSITIS, PSEUDOTUMOR, DISEASE, THERAPY, CYCLOSPORINE, RITUXIMAB, DACRYOADENITIS
  • Ankara Üniversitesi Adresli: Evet

Özet

Idiopathic orbital inflammation (IOI) is a benign inflammatory condition usually confined to the orbit but extraorbital extension can also occur. IOI has been classified into categories including anterior, diffuse, posterior or apical, myositis, and dacryoadenitis. Other rare types of IOI include periscleritis, perineuritis, and focal mass. Diagnosis is based on careful history, clinical findings, computed tomography, and magnetic resonance imaging findings. An orbital biopsy is usually done for accessible orbital lesions such as dacryoadenitis. For other types such as myositis and apical IOI where surgery is difficult or dangerous, orbital biopsy is not initially considered. The mainstay of therapy consists of systemic corticosteroids, but other options including external beam radiotherapy, antimetabolites, alkylating agents, T-cell/calcineurin inhibitors, lymphocyte inhibitors, tumor necrosis factor-alpha inhibitors, and surgical debulking have also been used.