Early-onset severe obesity due to complete deletion of the leptin gene in a boy

ÖZSU CAVGA E., Ceylaner S., Onay H.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.30, no.11, pp.1227-1230, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 11
  • Publication Date: 2017
  • Doi Number: 10.1515/jpem-2017-0063
  • Journal Name: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1227-1230
  • Keywords: childhood, leptin, monogenic obesity, RECEPTOR, DEFICIENCY, DYSFUNCTION, CHILDREN, RESISTANCE, MUTATION
  • Ankara University Affiliated: No

Abstract

Background: Monogenic obesity results from single gene mutations. Extreme obesity starting at an early age, especially in infancy, which is associated with endocrinopathy and metabolic disturbances is key to the diagnosis of monogenic obesity.