Impaired verbal memory and otherwise spared cognition in remitted bipolar patients on monotherapy with lithium or valproate

ŞENTÜRK CANKORUR V., Goker C., Bilgic A., Olmez S., Tugcu H., ÖNCÜ ÇETİNKAYA B., ...More

BIPOLAR DISORDERS, vol.9, pp.136-144, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1399-5618.2007.00481.x
  • Journal Name: BIPOLAR DISORDERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.136-144
  • Keywords: bipolar disorder, cognitive functions, euthymic, lithium, valproate, verbal memory, EUTHYMIC PATIENTS, NEUROPSYCHOLOGICAL DYSFUNCTION, AFFECTIVE-DISORDER, SCHIZOPHRENIA, INCREASES, HISTORY, BRAIN, IQ
  • Ankara University Affiliated: Yes

Abstract

Objectives: Patients with bipolar disorder have been reported to have neurocognitive deficits; however, it is not known whether the cognitive dysfunctions are state-dependent or a stable trait. Lithium and valproate, 2 of the most widely used mood stabilizers in the treatment of bipolar disorder, have also been associated with cognitive impairment. However, the degree and pattern of neurocognitive impairment in euthymic bipolar patients on either monotherapy with lithium or valproate have not been compared before in depth.