MDR1 gene polymorphisms may be associated with Behcet's disease and its colchicum treatment response

RÜSTEMOĞLU A., Gul U., GÜMÜŞ AKAY G., Gonul M., YİĞİT S., BOZKURT N., ...Daha Fazla

GENE, cilt.505, sa.2, ss.333-339, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 505 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.gene.2012.05.040
  • Dergi Adı: GENE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.333-339
  • Anahtar Kelimeler: Behcet's disease, ABCB1, SNP, Polymorphism, Turkey, RHEUMATIC AUTOIMMUNE DISORDERS, P-GLYCOPROTEIN ACTIVITY, CLOSE ASSOCIATION, EFFLUX PUMP, ABCB1 MDR1, T-CELLS, LYMPHOCYTES, EXPRESSION, ETIOLOGY, THERAPY
  • Ankara Üniversitesi Adresli: Evet

Özet

Behcet's disease (BD) is a chronic multisystem disorder. Infectious agents, immune system mechanisms, and genetic factors are implicated in the etiopathogenesis of BD, which remains to be explained. The human MDR1 (ABCB1) gene encoder P-glycoprotein (P-gp) plays a key role in drug disposition, serves as a protective mechanism against xenobiotics, and provides additional protection for the brain, testis, and fetus. We investigated the genotype and haplotype distributions of three MDR1 gene polymorphisms (C1236T, G2677T/A, and C3435T) in 104 BD patients and 130 control subjects. The genotyping analysis was performed by using PCR-RFLP methods.