MDR1 gene polymorphisms may be associated with Behcet's disease and its colchicum treatment response
GENE, cilt.505, sa.2, ss.333-339, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 505 Sayı: 2
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/j.gene.2012.05.040
- Dergi Adı: GENE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.333-339
- Anahtar Kelimeler: Behcet's disease, ABCB1, SNP, Polymorphism, Turkey, RHEUMATIC AUTOIMMUNE DISORDERS, P-GLYCOPROTEIN ACTIVITY, CLOSE ASSOCIATION, EFFLUX PUMP, ABCB1 MDR1, T-CELLS, LYMPHOCYTES, EXPRESSION, ETIOLOGY, THERAPY
- Ankara Üniversitesi Adresli: Evet
Özet
Behcet's disease (BD) is a chronic multisystem disorder. Infectious agents, immune system mechanisms, and genetic factors are implicated in the etiopathogenesis of BD, which remains to be explained. The human MDR1 (ABCB1) gene encoder P-glycoprotein (P-gp) plays a key role in drug disposition, serves as a protective mechanism against xenobiotics, and provides additional protection for the brain, testis, and fetus. We investigated the genotype and haplotype distributions of three MDR1 gene polymorphisms (C1236T, G2677T/A, and C3435T) in 104 BD patients and 130 control subjects. The genotyping analysis was performed by using PCR-RFLP methods.