Successful Desensitization of a Patient with Rituximab Hypersensitivity

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Ataca P., Atilla E., Kendir R., BAVBEK S., ÖZCAN M.

CASE REPORTS IN IMMUNOLOGY, cilt.2015, 2015 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2015
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1155/2015/524507
  • Dergi Adı: CASE REPORTS IN IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Ankara Üniversitesi Adresli: Evet

Özet

Rituximab is a monoclonal antibody which targets CD20 in B cells that is used for the treatment of CD20 positive oncologic and hematologic malignancies. Rituximab causes hypersensitivity reactions during infusions. The delay of treatment or loss of a highly efficient drug can be prevented by rapid drug desensitization method in patients who are allergic to rituximab. We report a low grade B cell non-Hodgkin lymphoma patient with rituximab hypersensitivity successfully treated with rapid drug desensitization. In experienced centers, drug desensitization is a novel modality to break through in case of hypersensitivity that should be considered.