Lysosomal mechanisms in PD
Collaborating with Pediatric Metabolism and Geriatrics within our University, in 2020, we started a study to define the prevalence of variants in the glucocerebrosidase (GBA) and galactocerebrosidase (GLA) genes in PD. Our further goal is to contribute to the clarification of lysosomal mechanisms in PD by further studies subjecting lysosomal enzymes and genetic modifiers.
Diversification of PD-related data
It has been widely acknowledged that the plurality of the existing data on PD is derived from Europe and North America, i.e., European ancestry, which is equivalent to only around 15% of the world’s population. This creates a huge bias in the interpretation of the data and hinders the generalization of current knowledge. In that sense, we aim to do our part of the job by providing data from Turkey and contributing to the diversification of PD-related knowledge. These include (but are not limited to) studies in genetic PD, deep brain stimulation, demonstrating attitudes of Turkish PD patients regarding COVID-19, prodromal PD, stigmatization etc.
Functional neurosurgical practice and research are performed in our institution since the 1960s by pioneering neurosurgeons (namely Nurhan Avman, Yücel Kanpolat, and Ali Savaş). Departments of Neurosurgery and Neurology are in close collaboration since 1993 with primary research interests in targeting techniques, cognitive effects of deep brain stimulation, and novel procedures in ablative surgery.
Clinical Outcome Assessments (Rating Scales)
Our group puts particular interest in the quantification of clinical data and its cultural adaptation. In accordance with this Turkish standardization of several rating scales are performed in collaboration with the International Parkinson and Movement Disorder Society (MDS), including the MDS Unified Parkinson’s Disease Rating Scale (MDS-UPDRS).