Investigation of GSTM1 and GSTT1 polymorphisms in obesity patients under bariatric surgery Bariatrik cerrahi olmuş obezite hastalarında gstm1 ve gstt1polimorfizmlerininaraştırılması

Ünsal A., Buluş H., Dirican O., Oğuztüzün S., Öztürk D., Cihan M., ...More

Fabad Journal of Pharmaceutical Sciences, vol.46, no.2, pp.139-146, 2021 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 2
  • Publication Date: 2021
  • Journal Name: Fabad Journal of Pharmaceutical Sciences
  • Journal Indexes: Scopus, EMBASE, International Pharmaceutical Abstracts
  • Page Numbers: pp.139-146
  • Keywords: GSTM1, GSTT1, Multiplex PCR, Obesity, Oxidative stress, Polymorphism
  • Ankara University Affiliated: Yes


© 2021 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.Obesity is a chronic disorder with increasing prevalence worldwide and occurs when energy intake is more than energy expenditure. Obesity is one of the factors that cause oxidative stress and arises from an imbalance between the reactive oxygen species ROS and the cell’s antioxidant defense system. Increasing ROS in obesity, influencing the hypothalamic neurons, affect hunger and satiety control, so correspondingly on body weight control. When ROS amount increases, through DNA, protein, and lipid oxidation, cell damage, necrosis, and apoptosis take place. Oxidative stress increment in adipose tissue causes the development of metabolic syndrome in obese people. Also, weight loss due to calorie restriction or exercise reduces oxidative stress. Mitochondria is the essential source for ROS formation. In the electron transfer system, reactive oxygen species forming due to oxidative phosphorylation reactions are involved in various physiological processes such as cell proliferation and differentiation. Glutathione S-transferase M1 and T1 genes encode enzymes that have oxidant-scavenging activities. Deletion polymorphisms in these genes cause the absence of their corresponding enzymes. In this study, we investigated the parameters associated with obesity such as body mass index (BMI), TSH, glucose, satiety blood glucose, triglyceride, and cholesterol levels, and deletion polymorphisms of GSTM1 and GSTT1 genes in 152 patients diagnosed with obesity in a Turkish population. No statistically significant relationship was found between the parameters studied in obese patients and GSTM1 and GSTT1 polymorphisms. More studies are needed to elucidate the relationship of GSTM1 and GSTT1 polymorphisms with obesity.