Cytotoxic activity of platinum(II) and platinum(IV) complexes bearing 5(6)-non/chlorosubstituted-2-hydroxymethyl benzimidazole ligands against HEp-2 cell line

Utku S., Gümüş F., Karaoǧlu T., ÖZKUL A.

Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.36, no.1, pp.21-30, 2007 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 1
  • Publication Date: 2007
  • Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus
  • Page Numbers: pp.21-30
  • Keywords: Benzimidazole, Cytotoxic activity, HEp-2 cell line, Platinum(II) complexes, Platinum(IV) complexes
  • Ankara University Affiliated: Yes

Abstract

In vitro cytotoxic activities of four platinum(II) and four platinum(IV) complexes with the structures [PtL2Cl2], [PtL 2I2] and [PtL2Cl4], [PtL 2Cl2(OH)2] (L= 5(6)-non/chlorosubstituted-2- hydroxymethyl benzimidazole ligands as "non-leaving groups") respectively were tested on the human HEp-2 (larynx carcinoma) cell line using Cell Culture Method. In general the complexes, which were found to be more active than carboplatin exhibited moderate cyctotoxicity comparable to cisplatin on the human HEp-2 cell line.