Pretransplant Consolidation Therapies Improve the Outcome of Myeloablative Allogeneic Transplantation in Adults with Ph-negative Acute Lymphoblastic Leukemia

Ozdemir, Zehra; Kircali, Ekin; Şahin, Uğur; Seval, GÜLDANE; Bozdağ, Sinem; Toprak, SELAMİ; Yuksel, MELTEM; Topcuoglu, PERVİN; Arslan, ÖNDER; Demirer, TANER; Ilhan, Osman; Beksac, MERAL; Gurman, GÜNHAN; ÖZCAN, MUHİT

doi:10.1016/j.clml.2022.02.007

Pretransplant Consolidation Therapies Improve the Outcome of Myeloablative Allogeneic Transplantation in Adults with Ph-negative Acute Lymphoblastic Leukemia

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Ozdemir Z. N., Kircali E., Şahin U., Seval G., Bozdağ S. C., Toprak S. K., ...More

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, vol.22, no.8, pp.596-600, 2022 (SCI-Expanded)

Publication Type: Article / Article
Volume: 22 Issue: 8
Publication Date: 2022
Doi Number: 10.1016/j.clml.2022.02.007
Journal Name: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
Page Numbers: pp.596-600
Keywords: Ph-acute lymphoblastic leukemia, Pre-transplant consolidation therapy, Allogeneic hematopoietic stem cell transplantation, First complete remission, Myeloablative conditioning, STEM-CELL TRANSPLANTATION, IMPROVED SURVIVAL
Ankara University Affiliated: Yes

Abstract

The benefit of pre-transplant consolidation treatments remains unclear in patients with acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, 57 patients with ALL who underwent allo-HSCT with myeloablative conditioning in first complete remission were evalu-ated. Overall survival was significantly better in patients receiving >= 2 consolidation compared to patients who receiving < 2 consolidation (P = 0.03).