Diaphragm unloading via controlled mechanical ventilation alters the gene expression profile

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DeRuisseau K., Shanely R., Akunuri N., Hamilton M., Van Gammeren D., ZERGEROĞLU A. M., ...More

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol.172, no.10, pp.1267-1275, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 172 Issue: 10
  • Publication Date: 2005
  • Doi Number: 10.1164/rccm.200503-403oc
  • Journal Name: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1267-1275
  • Keywords: gene expression, microarray, muscle atrophy, respiratory muscle, weaning from mechanical ventilation, RAT SKELETAL-MUSCLE, SOLEUS MUSCLE, OXIDATIVE STRESS, CONTRACTILE PROPERTIES, MESSENGER-RNA, IMMOBILIZATION ATROPHY, LIMB IMMOBILIZATION, PROTEIN-SYNTHESIS, DISUSE ATROPHY, SUPPLEMENTATION
  • Ankara University Affiliated: No

Abstract

Rationale: Prolonged controlled mechanical ventilation results in diaphragmatic inactivity and promotes oxidative injury, atrophy, and contractile dysfunction in this important inspiratory muscle. However, the impact of controlled mechanical ventilation on global mRNA alterations in the diaphragm remains unknown.